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4-MEC (BIG CRYSTALS)

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Description

DESCRIPTION

Buy 4-mec powder online, white crystalline powder, Buy mad cow powder, where to buy 4-mmc, buy 4-mmc pwder alaska: 4-Methylmethcathinone (mephedrone) is a designer drug of the phenethylamine class and shares substantial structural similarities with methcathinone (Schedule I).
Drugs from this class of compounds are known to produce central nervous system stimulation, psychoactivity and hallucinations.

Evidence from law enforcement indicates that the abuse of mephedrone as a recreational substance is widespread and growing. From 2009 to 2011, law enforcement agencies have documented mephedrone seizures throughout the United States. Mephedrone abuse has been associated with toxicity. Several cases of acute toxicity have been reported for the ingestion of mephedrone. Furthermore, deaths have been reported from the abuse of mephedrone.

Pharmacology

Mephedrone has been shown to inhibit the function of monoamine transporters and also serve as a substrate in vitro. It has been reported that mephedrone increases extracellular monoamines (serotonin and dopamine) concentration in rat brain as measured by in vivo microdialysis technique. Mephedrone has been reported to increase locomotor activity in rats. In drug discrimination assays mephedrone fully substitutes for methamphetamine
in rats trained to discriminate methamphetamine from saline. 3,4-methylenedioxymethamphetamine (MDMA) substitutes for mephedrone in rats trained to discriminate stimulus effects of mephedrone from saline. It has been reported that mephedrone is self-administered by rodents. Intracranial self-stimulation studies show that mephedrone, similar to cocaine, potentiates brain stimulation induced reward in mice. Similar to methamphetamine, mephedrone increases blood pressure and heart rate, cardiac output, ejection fraction, and stroke volume in rats. In a clinical studymephedrone produced stimulant-like subjective effects, impaired working memory and is associated with binge use. Individuals have presented at emergency departments following exposures to mephedrone. The adverse health effects reported for mephedrone are similar to those seen with other stimulant drugs. Adverse effects reported by abusers of mephedrone include increased heart rate, increased bloodpressure, chest pain, agitation, irritability, dizziness, delusions,nose bleeding, dilated pupils, seizures, nausea and vomiting. There have been reports of deaths in which mephedrone was either implicated or ruled as the cause of death. According to self-reported drug users, the amounts for snorting mephedrone ranged from 25 to 75 milligrams but for oral administration it ranged from 150 to 250 milligrams. Following oral or nasal ingestions of mephedrone, users report that desired effects occur 15 to 45 minutes after administration.

User Population

Mephedrone is popular with youths in urban environments with males appearing to use synthetic cathinones more than females. Information also suggests that mephedrone is used
by several population groups such as young adults, mid-tolate adolescents, and older adults.

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